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Faculty Profile Last Modified Time: 12:52:01 PM Tue, 16 Jul 2024   Contact Information John F. Hancock Associated Profiles  Executive Dean of McGovern Medical School, Executive Director, Institute of Molecular Medicine, Professor, John S Dunn Distinguished University Chair, Physiology and Medicine, UT Health Science Center Houston   Medical School Building, Room No.: 4.098C    John.F.Hancock@uth.tmc.edu     713-500-7547    Web Link    Cell Membrane, Ras Proteins, Cell Membranes, Membranes, Lipids, Caveolae, Guanosine Triphosphate, Caveolins    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Dr. Hancock's laboratory studies basic mechanisms of mammalian cell signaling. He is especially interested in the function of Ras proteins. These small GTP binding proteins operate as molecular switches in signal transduction pathways and are present in a mutant, activated state in many human tumors. Understanding the basic biology of Ras has major implications for the development of novel anticancer therapeutics. The laboratory uses advanced live cell imaging, electron microscopy, proteomics and mathematical modeling to study how the Ras membrane anchors cooperate with the G-domain and peptide sequences flanking the anchor to drive lateral segregation into dynamic nanodomains, called nanoclusters. This work has generated new models of how lipidated proteins interact with, and use, the plasma membrane to generate signaling platforms and has revealed how the confinement of signaling complexes in plasma membrane nanodomains regulates the kinetics, sensitivity and fidelity of signal transmission. Related projects are focused on characterizing the mechanisms whereby K-ras, the Ras that protein that drives the largest number of human tumors, is transported to the plasma membrane after posttranslational processing on the endoplasmic reticulum. Recent novel insights from these basic scientific programs have been translated into drug discovery programs.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX  Training Grants Training Interdisciplinary Pharmacological Scientists The Cancer Therapeutics Training Program (CTTP)  Appointments Title Department / School Institution Executive Dean McGovern Medical School UT Health Science Center Houston

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