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Faculty Profile Last Modified Time: 10:39:57 AM Tue, 7 Apr 2020   Contact Information Claire Elizabeth Hulsebosch Associated Profiles  Professor, Department of Neurobiology and Anatomy, UT Health Science Center at Houston     Claire.Hulsebosch@uth.tmc.edu     713.500.5090    Web Link    Spinal Cord Injuries, Hyperalgesia, Spinal Cord, Nerve Growth Factor, Neuralgia, Chronic Pain, Spinal Nerve Roots, Axons    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Spinal cord injury results in a variety of changes that continue to be cytotoxic to cells that are at risk of dying, both nerve cells and glial cells-cells that are not nerve cells but are critical for normal spinal cord function. Her group reports that both glial and nerve cells are changed permanently after spinal cord injury. They are in the process of using molecular, behavioral, physiological, immunocytochemical and electrophysiological approaches to study the mechanisms that underlie the permanent changes that will help restore the spinal cord to normal function. Her collaborative manuscripts demonstrate numerous and permanent changes that are many segments above and below the spinal cord injury and persistent changes in neural circuits in these regions that lead to dysfunction. One project is focused on recovery of normal sensory/motor function; another project focuses on improved visceral function, while other projects test the role of transplanted stem cells. For example, her laboratory has demonstrated that molecularly engineered cells transplanted onto the surface of the spinal cord can return the abnormal characteristics of the nerve cells that develop after SCI, to more normal behavior. They hypothesize that persistent neuroinflammation in the spinal cord contributes to permanent alterations in nerve cell circuits, and that the abnormal reaction of microglia and astrocytes after SCI (she calls this "gliopathy"), even many segments away continues to contribute to the neuroinflammation leading to impaired nerve cell function. Insight into these pathways will suggest therapeutic intervention strategies.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Translational Pain Science Gulf Coast Consortium for Translational Pain Research  Appointments Title Department / School Institution Professor Neurobiology and Anatomy UT Health Science Center Houston

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