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Faculty Profile Last Modified Time: 09:53:06 AM Thu, 20 Jun 2024   Contact Information Jokubas Ziburkus Associated Profiles  Associate Professor, Biology & Biochemistry, University of Houston   Health and Biomedical Sciences Building, Room No.: 438    jziburkus@uh.edu     (713) 743-0659    Web Link    Immunohistochemistry, Cell Signaling, Neuroscience, Electrophysiology, Physiology, Pharmacology, Neuron, Synaptic Plasticity, Epilepsy, Synaptic Transmission, Rats, Patch Clamp, Neuromodulation, Kinase Inhibitors, Voltage Clamp    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   The long-term goal of Dr. Jokkbas Žiburkus' laboratory research is to understand the mechanisms of neuronal interactions in health and disease and to devise novel and alternative therapeutic treatments for untreatable neurological disorders. The lab employs a multi-disciplinary approach that synthesizes in vitro neurophysiology, neuropharmacology, imaging, molecular biology, immunohistochemistry, and computational neuroscience. Using these techniques, Žiburkus is trying to understand alterations in single neurons and neural networks that lead to epileptic seizures, abnormal excitability in Alzheimer's disease, or occur following a traumatic brain injury. His lab has filed and continue developing patents for novel and combinatorial medications to treat neurological disorders, stroke, and even cancer. Recent work has focused on Dravet syndrome – a severe form of childhood epilepsy that is very hard to treat. Žiburkus is investigating how purines affect mortality, seizures, and other behavioral comorbidities in a transgenic mouse model of Dravet syndrome. He is also investigating other alternative compounds and their combinations for treatment of brain and heart hyperexcitability, seizure activity, and even cancer.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC for Theoretical Neuroscience Gulf Coast Consortium for Theoretical and Computational Neuroscience  Appointments Title Department / School Institution Associate Professor Biology and Biochemistry University of Houston

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