The Cancer Genome Atlas, Bioinformatics, Systems Biology, Genomics, Proteomics, Computer Science, Neoplasms, Genes, Cell Line, Liposomes, Atlases, National Cancer Institute (U.S.), Genome, Mutation
Dr. John N. Weinstein M.D., Ph.D. is a Professor and Chair of Dept of Bioinformatics and Computational Biology and Professor of Dept of Systems Biology at University of Texas M. D. Anderson Cancer Center. Since 1991, Dr. Weinstein has applied a mix of genomic, proteomic, systems biological, and bioinformatic tools to the pursuit of new biomarkers, new prevention strategies, and new therapies for cancer. His research program (for which he has coined the term 'integromic') is part experimental, part computational. Using more than two dozen microarray platforms and other high-throughput technologies, he and his collaborators have generated interoperable molecular profile databases on cancer cells at the DNA, RNA, protein, chromosomal, functional, and pharmacological levels. Overall, its the most comprehensive molecular profiling of any panel of cells to date. Potential clinical results have flowed from the molecular profiles and the analyses of them. For example, his analyses in the 1990's were critical to the go-no go decision for clinical development of oxaliplatin, now a standard agent for treatment of colorectal cancer. Dr. Weinstein make research on Molecular Pharmacology of Cancer Cells utilizing techniques such as gene expression profiling and bioinformatics, and the identification and characterization of new agents for the treatment of cancer.
Publications/Creative Works
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