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Faculty Profile Last Modified Time: 06:51:23 AM Wed, 15 Apr 2020   Contact Information Emil Martin Associated Profiles  Associate Professor, Cardiovascular Medicine, UT Health Science Center at Houston   Behavioral and Biomedical Sciences Building, Room No.: 5.312    Emil.Martin@uth.tmc.edu     713-486-2441    Web Link    Guanylate Cyclase, Nitric Oxide, Heme, Soluble Guanylyl Cyclase, Proteins, Carbon Monoxide, Trans-Activators, DNA-Directed RNA Polymerases    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   In one line of studies we investigate the molecular mechanisms responsible for the conversion of exogenous nitric oxide signal into intracellular messenger molecule cGMP. This conversion is performed by NO receptor, a cytosolic soluble guanylyl cyclase (sGC). Using recombinantly expressed human sGC we investigate the molecular events leading to sGC by nitric oxide. In addition to NO-dependent regulation, we also explore alternative NO-independent methods of sGC regulation, including regulation by cellular thiols, nucleotides, interacting proteins and protein kinases. Mechanisms of action of pharmacological agents known to modulate sGC function in cells and whole organisms are investigated. We have recently identified a number of naturally occurring compounds which activate sGC not only in vitro, but also regulate sGC function in vivo, e.g. induce sGC-mediated relaxation of vascular smooth muscles, regulation of blood pressure. We are currently exploring this as a potential method of NO-independent modulation of sGC physiological function, especially in cardiovascular health. In another line of investigation we study the regulation of gene transcription by cGMP. Microarray gene expression profiles were employed to identify genes responsive to variation in intracellular cGMP concentrations. Of particular interest are the genes regulated independently on cGMP-dependent protein kinase.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics  Appointments Title Department / School Institution Associate Professor Cardiovascular Medicine UT Health Science Center Houston

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