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Faculty Profile Last Modified Time: 12:12:44 PM Thu, 8 Dec 2022   Contact Information Junji Iwahara Associated Profiles  Professor, Biochemistry and Molecular Biology, UT Medical Branch at Galveston   Mail Box: 1068, Medical Research Building, Room No.: 5.104B    j.iwahara@utmb.edu     409-747-1403    Web Link    Lab Webpage    DNA, Proteins, Nuclear Magnetic Resonance, Lysine, Nuclear Magnetic Resonance Spectroscopy, Magnetic Resonance Spectroscopy, Biomolecular Nuclear Magnetic Resonance, Zinc Fingers    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Macromolecular binding event is not simply a two-state exchange between free and bound states. In fact, previous kinetic investigations have suggested that the process of the specific complex formation goes through intermediate states called as target search or encounter complexes and the presence of such intermediates greatly accelerates the overall process. In terms of structure, how do individual components bind to each other at the intermediates states? How dynamic are they? These are fundamentally important questions for understanding macromolecular recognitions, while structural biology has not given adequate answers yet. It is because the very low population at equilibrium and dynamic nature of such states make the investigations extremely difficult. We have developed a number of powerful NMR methods that permit characterization of the intermediates in macromolecular binding at equilibrium. Applying the new techniques, we investigate structural and dynamic aspects of binding intermediates. Currently, the focus in our research is on the target search process whereby gene-regulatory proteins are able to efficiently and rapidly locate their specific DNA target sequence in a sea of non-specific DNA.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn, Sr. GCC for Magnetic Resonance GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Biochemistry and Molecular Biology UT Medical Branch at Galveston

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