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Faculty Profile Last Modified Time: 08:55:18 AM Mon, 20 Apr 2020   Contact Information Hye-Jeong Yeo Associated Profiles  Associate Professor, Biology and Biochemistry, University of Houston   Houston Science Center, Room No.: 448    hyeo@uh.edu     (713)743-8377    Web Link    Structural Biology, Protein Crystallography, Antimicrobial Resistance    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Dr. Hye-Jeong Yeo's research interests center on the structure determination of bacterial virulence factor proteins by X-ray crystallography and functional analysis of these proteins using a combination of biochemical and biophysical methods. Her lab studies proteins involved in bacterial secretion systems and bacterial lipoproteins, as possible vaccine and drug targets against infectious diseases. One ongoing project is to study three fascinating proteins (HMW1, HMW1B and HMW1C) of the HMW1 adhesin secretion pathway in Haemophilus influenzae, a common cause of localized respiratory tract diseases. Bacterial attachment to the respiratory epithelium plays an important role in infection and is influenced by adhesive proteins called adhesins. The HMW1 adhesin is a key virulence exoprotein secreted via the Two-Partner Secretion pathway. A detailed structural and functional understanding of the HMW1 secretion strategies cooperated with HMW1B (outer membrane protein) and HMW1C (N-glycosyltransferase) should provide insights into one of the major bacterial secretion mechanisms. Another project is to investigate a variety of novel virulence factor proteins from Campylobacter jejuni, a leading cause of human gastrointestinal infections. Bacterial lipoproteins are universal components of the membranes and have diverse functions. Some of the lipoproteins that are upregulated, once inside the mammalian host, undergo antigenic variations as a strategy of evading the host immune response. Lipoproteins are also involved in disease pathogenesis through their ability to trigger the host inflammatory response. Surface-exposed lipoproteins are often implicated in essential roles in the interaction with mammalian host cells. Yeo seeks to discover novel lipoproteins of C. jejuni and explore their potential as vaccine candidates.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC for Protein Crystallography  Training Grants Houston Area Molecular Biophysics Training Program  Appointments Title Department / School Institution Associate Professor Biology and Biochemistry University of Houston

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