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Faculty Profile Last Modified Time: 07:49:16 AM Tue, 7 Apr 2020   Contact Information Jane Grande-Allen Associated Profiles  Isabel C. Cameron Professor and Chair, Bioengineering, Rice University   BioScience Research Collaborative, Room No.: 619    grande@rice.edu     (713) 348-3704    Web Link    Lab Webpage    Finite Element Modeling, Biomaterials, Solid Mechanics, Composites, Biomedical Engineering, Regenerative Medicine, Biomaterial Science, Cardiovascular, Aortic Valve, Mitral Valve, Extracellular Matrix, Collagen, Glycosaminoglycans, Proteoglycans, Elastin    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   The overall focus of our research is to characterize and eventually to manipulate the structure-function-environment relationship of cardiac valves in an integrative fashion (cellular, tissue, organ, and clinical). The matrix composition and material properties of heart valves are believed to be determined by the load patterns imposed during valve function. Consequently, alterations to the normal tissue loading patterns will affect the cellular phenotypic production of extracellular matrix and transform the valve morphology, mechanics, and function. To relate tissue composition and mechanics in leaflets and chordae from normal and diseased mitral valves, our laboratory performs mechanical testing, biochemical measurements, and microstructural analysis of the extracellular matrix (especially glycosaminoglycans (GAGs) and proteoglycans) of these tissues. These techniques have allowed us to gain understanding about the extracellular matrix (ECM) that underlies the mechanical behavior of valves, and how the ECM varies across the valve microstructure. We then correlate these data with echocardiographically assessed cardiac functional parameters and clinical demographics. We are also using cells, organ cultures, and tissue engineering approaches to investigate valve disease from a more mechanistic angle. The main diseases that we study are myxomatous ("floppy") mitral valve disease, calcific aortic valve disease, and secondary remodeling of the heart valves in patients with heart failure, but this research may have implications and applications for other soft tissues. Our goal in characterizing the normal and pathological mechanisms of valvular remodeling is to derive novel surgical and medical therapies that can be used to treat patients earlier in the disease process.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Regenerative Medicine  Appointments Title Department / School Institution Isabel C. Cameron Professor and Chair Bioengineering Rice University

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