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Faculty Profile Last Modified Time: 10:13:04 AM Fri, 17 Apr 2020   Contact Information Zahid H Siddik Associated Profiles  Professor, Pharmacology, Experimental Therapeutics, MD Anderson Cancer Center   MDA 3SCR3.3420, Room No.: Unit 1950    zsiddik@mdanderson.org     713-792-7746    Web Link    Platinum, Cisplatin, Carboplatin, Ormaplatin, Neoplasms, Pharmaceutical Preparations, Rats, Pharmacokinetics    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   My interests are in mechanisms of drug resistance, particularly in cancers retaining the p53 tumor suppressor in its wild-type state. Normally, the presence of wild-type p53 in cancers provides an apoptotic stimulus and imparts high tumor cell sensitivity to therapeutic agents. In resistant cancers, however, wild-type p53 fails to activate cell cycle checkpoint response and induce the apoptotic stimulus. The goal in my laboratory is to undertake hypothesis-driven studies to define pathways responsible for this loss of p53 function and rationally investigate designer drugs to reactivate the tumor suppressor and provide a basis for translational opportunities. Such an approach is essential for improving response rates in the clinic. In our laboratory, we use a variety of analytical tools to assess pharmacological (e.g., drug concentration at the cellular level and target sites), biochemical (e.g., checkpoint kinase activity and proteomic analysis), and molecular (e.g., target activation, microarrays and siRNA) drivers of cytotoxic drug response and their modulation in sensitive and resistant tumor models. There are ample opportunities to network with other labs with mutual interests.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics  Appointments Title Department / School Institution Professor Pharmacology MD Anderson Cancer Center

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