The goal of our laboratory is to define the molecular pathways that regulate muscle performance and muscle metabolism and how these pathways are altered in disease. In striated muscle, intracellular Ca2+ signaling is an intrinsic component of signal transduction pathways that regulate vital aspects of muscle function including contractility and metabolism. We use animal models to study how alterations in Ca2+ homeostasis affect the key pathways that dictate a muscle's ability to modulate force production, fatigue and energy expenditure.
Publications/Creative Works
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