Barrett, Alan (Faculty Profile)

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Faculty Profile

Last Modified Time: 01:43:06 PM Tue, 31 Mar 2020

Contact Information
Alan Barrett	Associated Profiles
Professor, Pathology, and Director, Sealy Center for Vaccine Developemnt, UT Medical Branch at Galveston


abarrett@utmb.edu (409) 772-6662 Web Link
West Nile Virus, Yellow Fever Virus, Viruses, Vaccines, Flavivirus, Japanese Encephalitis Virus, Yellow Fever Vaccine, Yellow Fever

Research and Expertise
Affiliations
Appointments

Research and Expertise

Research Interests

Our laboratory is undertaking basic research on the development of vaccines against the flavivirus diseases. This includes West Nile, Japanese encephalitis, yellow fever and dengue. We undertake studies on the excellent yellow fever 17D vaccine as a model to understand the molecular basis of attenuation of this vaccine. This is of major importance as the 17D vaccine virus is being used as an attenuated backbone to generate chimeric vaccine viruses against other flavivirus diseases, including dengue and Japanese encephalitis. In addition, recombinant DNA technology and infectious clone technology/reverse genetics are being used to identify molecular determinants of virulence of yellow fever, West Nile and Japanese encephalitis viruses with the aim of mutating these virulence determinants to develop candidate attenuated vaccine strains. We also investigate the moelcular epidmeiology of various flaviviruses (yellow fever, West Nile, Japanese encephalitis, and St Louis encephalitis viruses).

Publications/Creative Works

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Affiliations

Research Consortia

John S. Dunn GCC for Chemical Genomics

Appointments

Title	Department / School	Institution
Professor	Pathology	UT Medical Branch at Galveston

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