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Faculty Profile Last Modified Time: 07:47:34 AM Thu, 16 Apr 2020   Contact Information Javier Navarro Associated Profiles  Professor, Neuroscience and Cell Biology, UT Medical Branch at Galveston   Mail Box: 1069, Medical Research Building, Room No.: 2.104C    jnavarro@utmb.edu     409-772-5480    Web Link    Interleukin-8, Interleukin-8 Receptors, Neutrophils, Interleukin-8B Receptors, Aryl Hydrocarbon Hydroxylases, Chemokine Receptors, Chemical Activation, Guinea Pigs    Associated Profiles Research and Expertise Appointments  Research and Expertise Research Interests   Our work focuses on elucidating the molecular mechanisms of G protein-coupled receptors. These are seven-helix transmembrane receptors acting as detectors of signals including odor, light, hormones, neurotransmitters, and as mediators for the entry of HIV-1. Genes encoding these receptors occupy a hefty 3% of the human genome. Of importance is that these receptors are the target of about 60% of drugs used to treat human diseases. In my laboratory we are applying X-ray crystallography to elucidate the atomic structure of seven-helix transmembrane receptors. Genetic and biophysical approaches are also applied to determine the role of specific domains on the function of these receptors. We are also investigating the molecular mechanisms underlying the chemokines-regulated the inflammation-neurogenesis coupling.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Professor Neuroscience & Cell Biology UT Medical Branch at Galveston

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